News
February 2026. We congratulate Dr. Yang on his promotion to Associate Professor with tenure!
August 2025. Congratulations to Dr. Cameron Bryan on defending her Ph.D. thesis. Cameron is the third Ph.D. in the lab.
November 2024: Welcome Dr. Yogesh Khetmalis, our new postdoc. Yogesh obtained his Ph.D. in Chemistry from Birla Institute of Technology and Science, India.
November 2024: Congratulations to Dr. Ying Peng on defending her Ph.D. thesis. Ying is the second Ph.D. in the lab.
November 2024: Congratulations to Cameron Bryan on her new publication in ChemBioChem. Cameron characterized OGG1-DPC and determined that OGG1 cross-links to the incised AP site via cysteine and histidine addition.
October 2024: Congratulations to Dr. Xiaoying Wei on defending her Ph.D. thesis. Xiaoying is the first Ph.D. in the lab. Best of luck at Asieris Pharmaceuticals!
August 2024: Bingru Li and Peixin Wang joined the lab. Both Bingru and Peixin are first year CBMC graduate students. Welcome!
July 2024: The Yang lab received an R35 (MIRA) Award from the NIGMS. This 5-year MIRA will support our research program that is focused on DNA-protein cross-links (DPCs).
February 2024: Congratulations to Cameron for receiving the 2024-2025 University Graduate Continuing Fellowship.
January 2024: Joel Cepeda joined the lab. Joel is the first year CBMC graduate student. Welcome Joel.
January 2024: Congratulations to Ying Peng's publication in Chemical Research in Toxicology Ying developed a LC-MS/MS workflow to characterize 3'-histone-DPCs and showed that these adducts are endogenous DNA lesions in HEK293T cells.
August 2023: Xiaoying, Cameron, and Ying presented their work in 2023 Fall ACS meeting. Both Xiaoying and Cameron won the Outstanding Oral Presentation Award from TOXI. Congratulations!
May 2023: Congratulations to Ying Peng's publication in Bioconjugate Chemistry. Ying developed a chemical approach to synthesize stable and site-specific 3'-end DNA-histone cross-links, and demonstrated that the DPC repair efficiency is highly affected by the local protein environment, and prior DPC proteolysis facilitates the repair.
April 2023: Congratulations to Xiaoying Wei's publication in Biochemistry. Xiaoying demonstrated that Poly [ADP-ribose] polymerase 1 incises abasic sites and covalently cross-links to 3′-DNA termini via cysteine addition not reductive amination.
April 2023: Congratulations to Cameron Bryan's publication in DNA Repair. Cameron showed that apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links.
February 2023: Congratulations to Xiaoying for receiving the 2023-2024 University Graduate Continuing Fellowship.